Abstract: An Earth system model is an important tool for studying the TC (tropical cyclone) activities affected by climate change. Previous studies have shown that the high-resolution version of the NUIST Earth system model (NESM) can simulate the global SST distribution and climate characteristics of the TC activity. Compared to the TC activity observed from 1967 to 2016, this study analyzed the interannual variability of the TC activity in the Northwest Pacific Ocean simulated by the NESM model. The results show that the high-resolution version of the NESM model can simulate the mean SST in the Northwest Pacific and the SST anomalies associated with ENSO events. This model could simulate the generation frequency and the path distribution of TCs in the Northwest Pacific when El Niño events occur. The simulation showed that the position of TCs in El Niño years was more easterly than in the La Niña years. However, the correlation between the mean life of TC and Niño3.4 SST could not be simulated. Moreover, the generation position of TCs in La Niña years simulated by the model is easterly than observation, mainly because the average position of the monsoon trough in the simulated La Niña years is eastward. These results can help improve the NESM model studying TC activities.