Abstract: The strongest recorded El Niño event of the 21st century occurred globally from autumn 2015 to spring 2016. Unlike traditional events, this super El Niño had complex spatiotemporal effects on near-surface ozone concentrations in East Asia, characterized by alternating positive and negative ozone anomalies across different regions and time periods. This study finds that the reduction in ozone concentrations in China during the El Niño event is closely related to anomalous southerly winds. These winds transport clean marine moisture, resulting in increased precipitation while simultaneously weakening solar radiation, increasing relative humidity, and lowering temperatures, thereby inhibiting the photochemical production of ozone. Specifically, from December 2015 to April 2016, southern regions such as Fujian and Guangdong experienced significantly lower ozone levels due to persistent southerly winds. In the Yangtze River basin, ozone levels were also lower during winter (December to January). However, from February to March, the effects of El Niño weakened, leading to a positive ozone anomaly. By May, as the influence of El Niño shifted northward, anomalous southerly winds once again dominated the middle and lower reaches of the Yangtze River and the Huai River basin, resulting in decreased ozone concentrations once again. This study elucidates the mechanisms linking El Niño events to regional ozone pollution, providing a scientific basis for predicting ozone concentrations across seasons and developing pollution control strategies in East Asia.