Abstract: Prof. Ye Duzheng was one of the very pioneers who initiated and led the global change studies in the world, and he was also the main founder of the global change studies in China. In this paper, his activities related to global change since the 1980s is provided together with detailed literature. A brief review and reminiscence of his main ideas on (1) the climatic-ecologic zones sensitive and vulnerable to global change; (2) the linkage between the adaptation to global change and sustainable development; (3) orderly human activities is also provided. It is pointed out that Prof. Ye’s ideas and contributions to global change studies, with the characteristic of combining theory with practice, are deeply rooted in his early research career and in his understanding on and responsibility to China, the world, and the humankind. All of these ideas and responsibilities, and also his capability in the leadership and coordination of international cooperation are worthwhile to be followed by the newer generations of scientists working for a sustainable and habitable Earth.