Abstract: Herein, atmospheric ice nuclei gradient observation results from Huangshan and Shenyang were used as a representative. Using advanced international instruments for atmospheric ice nuclei observation and Bigg-type mixed and diffusion cloud chambers combined with meteorological element observation equipment, variation in the atmospheric ice nuclei number concentration with height, time, temperature, humidity, and particle size in Huangshan and Shenyang of China is analyzed. Two main mechanisms of atmospheric ice nuclei under different space locations, environmental conditions, and particle sizes are obtained. Finally, based on the above observations and research results, the parameter schemes of atmospheric ice nuclei in typical areas of northern and southern China are fitted with parameter formulas, and the attribute differences of atmospheric ice nuclei number concentration and nucleation mechanism in northern and southern China are finally obtained. Thus, it provides a theoretical basis for different artificial precipitation reduction operations in northern and southern China.