Abstract: Using the weather research and forecasting model (WRF), two typical climate years were selected to study different water storage periods of the Three Gorges Reservoir, that is the high water level period in 2011 and the high temperature and low water level in 2022. Two sets of numerical experiments were designed to investigate the possible impact of water-level changes during the dynamic operation of the Three Gorges Reservoir on the climate of the reservoir area. The results indicate the following: 1) The WRF model simulations show that climate elements in the reservoir area change to a certain extent. During both low and high water level storage periods, the widening and rising of the reservoir’s water body locally affect climate variables such as temperature, wind, relative humidity, and precipitation. However, the scope and magnitude of these changes vary with varying water levels. 2) Near the water body, temperature decreases while relative humidity and wind speeds increase. These variations are mainly concentrated near the reservoir, with minimal impact on corresponding meteorological elements far from the water body. 3) Changes in precipitation within the reservoir area are relatively complex, showing a slight increase. Factors contributing to increased precipitation during the flood season include terrain, air stratification, and water vapor content, which all have important impacts on precipitation in mountainous areas.