Abstract: Using surface sensible heat data over the Qinghai–Xizang Plateau based on the maximum entropy production principle, along with National Centers for Environmental Prediction / National Center for Atmospheric Research (NCEP/NCAR) reanalysis data and meteorological station observations, the quasi-2-year cycle characteristics of July surface sensible heat over the Qinghai–Xizang Plateau were investigated using the multitaper method combined with singular value decomposition. Results show a significant quasi-2-year cycle of July surface sensible heat on the Qinghai–Xizang Plateau from 1980 to 2018, manifested in alternating eastern and western reverse anomalies. As direct influencing factors on sensible heat, surface winds and ground–air temperature differences contribute positively to this cycle, with the latter having a larger contribution. Synergistic analysis of atmospheric circulation and sea surface temperature (SST) reveals that under a typical quasi-2-year cycle of July surface sensible heat over the Qinghai–Xizang Plateau, the La Niña phase appeared in the east-central equatorial Pacific Ocean in late spring/early summer of the first year and gradually developed and strengthened. Then, in July, the subtropical high pressure deviated northward and westward, and the subtropical westerly rapids deviated northward, which resulted in anomalous low-level divergence (convergence) and anomalous high-level convergence (divergence) as well as anomalous sinking (ascending) motions over the east-central (western) Qinghai–Xizang Plateau. This form of circulation is unfavorable (favorable) for cloud generation in the eastern (western) part of the Qinghai–Xizang Plateau. Reduced cloud cover in the eastern (western) part of the plateau makes the ground receive more (less) solar radiation, which causes an increase (decrease) in the ground–air temperature difference and ultimately leads to a greater (smaller) sensible heat. In summary, under a quasi-2-year cycle of July sensible heat over the Qinghai–Xizang Plateau, in the first year, La Niña strengthens, the subtropical high pressure over the western Pacific Ocean shifts northward and westward, and the subtropical westerly rapids in East Asia shift northward; consequently, surface sensible heat over the Qinghai–Xizang Plateau is strong in the east and weak in the west. The anomalies of atmospheric circulation and SST in the second year are opposite to those in the first year, resulting in surface sensible heat over the Qinghai–Xizang Plateau being weak in the east and strong in the west.